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Facility Design and Expansion: Commissioning for Innovation
Once guiding principles are identified, designers can explore the
most cost-effective methods for delivering a flexible, expandable
site. A modern biotechnology facility resembles a living organism, constantly evolving and changing. As research programs change, so do the requirements for equipment, staff, and laboratory space.
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The Next Generation of Aseptic Processing Equipment
The industry has acknowledged only recently the significance of the
contamination risk posed by humans. The authors assert that this
realization, together with technological advances, will lead to the elimination of human intervention and, hence, improved
sterility.
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Real-time PCR: Advancing RNA Interference and MicroRNA Studies
In recent years, researchers have made great strides toward understanding the role of endogenous small RNAs (miRNAs) in gene regulation and harnessing the power of exogenous small RNAs (siRNAs and shRNAs) as laboratory tools to manipulate messenger RNA (mRNA) levels. As the field has evolved, methods to identify, quantify and regulate these RNAs also have evolved. Now, a new miRNA assay that employs stem-loop primers allows researchers to easily and effectively assess small RNAs and greatly enhances the power of quantitative real-time PCR for small RNA studies.
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Immobilization of Oligonucleotides on a Silicon Surface
A new method for affixing DNA oligonucleotides to silicon surfaces increases signal intensity 20-fold compared to glass, enabling a silicon field-effect electrolyte-insulator-semiconductor (EIS) sensor that directly detects DNA hybridization.
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