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New therapies to achieve glycemic control and weight loss in T2DM
Today's management of type 2 diabetes mellitus is supported by an array of therapeutic agents, including new drugs approved in 2005 that can promote weight loss along with glycemic control—pramlintide and exenatide—and an inhaled insulin, which was approved in 2006.
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Consider metabolic syndrome a combination of different conditions
No wonder metabolic syndrome is called syndrome X. Instead of being recognized as a separate disease, it is considered a constellation of many conditions. "The biggest problem is a failure to address the underlying problem—insulin resistance," says Robert Epstein, MD, chief medical officer for Medco Health Solutions in Franklin Lakes, N.J. He calls metabolic syndrome one of the country's top five health problems.
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Global guidelines launched for Type 2 diabetes
The International Diabetes Federation (IDF) launched the first global evidence-based guidelines for Type 2 diabetes at the September meeting of the European Association for the Study of Diabetes, in Athens. Diabetes afflicts more than 194 million people worldwide. "Estimates and projections agree that the number of diabetes cases that may be reached in the next 25 years would qualify as the largest epidemic humanity has ever experienced," said Philip Home, joint chair of the IDF Task Force on Clinical Guidelines.
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Hypopituitarism in older adults
Patients with hypopituitarism may present with many different signs and symptoms which result from reduced secretion of one or more of pituitary hormones. Severe hyponatremia and hypoglycemia are rare but potentially life threatening presenting clinical features of hypopituitarism. As these abnormalities are completely restored with replacement therapy and patients are often undiagnosed until admission, a high clinical suspicion is necessary to diagnose a patient with hypopituitarism. We present five cases exhibiting rare symptoms of hypopituitarism?severe hyponatremia, hypoglycemia and osteoporosis?as the only presenting feature; these cases illustrate that hypopituitarism must be considered in the differential diagnosis of these abnormalities, especially in older patients.
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