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Gas Selection/Management for the Biotech Lab
Managing specialty gases and cryogenic liquids can create a variety of headaches and hassles for life sciences laboratories. Selecting the right grades and quantity is not easy. Upon arrival, a gas supply system must safeguard purity to the point of use. Labs also need to maintain enough cryogens, like liquid nitrogen, carbon dioxide, and dry ice, to preserve their work. Yet cryogens vaporize over time.
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Interconnected Signaling Pathways Rethinking Drug Specificity as a Desirable Objective
Intracellular signaling occurs through cascades of interconnected/interdependent networks, rather than through linear pathways. Because effector molecules modulating this network typically function in both redundant and pleiotypic fashion, selective modulation of a single intracellular signaling pathway seems highly improbable.
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"Moving Gene Expression Microarray Data to the Clinic – An Analytical Requirements Perspective"
DNA microarrays are used to measure relative transcript abundance in RNA samples, allowing researchers to identify differences in gene expression. To date gene expression microarrays have predominantly served discovery based research efforts, however, recent technological improvements and standardization initiatives, as well as need driven incentives, have opened the possibility of using this high-complexity analytical test in both pre-clinical and clinical settings.
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RNAi: A Robust Tool For Target Identification And Validation
The application of RNA interference (RNAi) to mammalian cells has significantly accelerated research in functional genomics and drug discovery. RNAi allows simple, effective, and specific downregulation of mammalian gene expression, making it a powerful and accessible technique with enormous scientific, commercial, and potential therapeutic value.
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